RNA interference therapy

RNA interference therapy

RNA interference therapy has got a significant importance in recent era. The mechanism bhind RNA Interference is not fully understood, but it was observed that, gene silencing effects occur, after the process of transcription. It could be explained as ds RNA which was created to target the introns are spliced out of mRNA. The main process of RNAi is cutting of dsRNA into smaller pieces of desired length by using appropriate enzyme. The enzyme used in this process is called as Dicer. Dicer cleaves double stranded RNA into two small RNAs microRNA (MiRNA) and small interfering RNA. MiRNA Stops protein production,RNA dependent on the sequence specific interactions between SiRNA and MRNA. RNAi silences expression gene